Fig. 1 –

Overview. Experimental strategy showing: (A) functional analyses of Nkx3.1 GEMMs in vivo (schematic for Fig. 2), (B) functional analyses of human LNCaP prostate cancer cells in vitro and in vivo (schematic for Fig. 3 and 4), and (C) functional and correlative analyses of human patient samples including (C.1) organ cultures, (C.2) TMAs, and (C.3) biopsy cohorts (schematic for Fig. 5). See the text for further details.

AS = active surveillance; GEMM = genetically engineered mouse model; ROS = reactive oxygen species; RP = radical prostatectomy; TMA = tissue microarray; w/out = without.