Table 2.
Donor characteristics for 1,156 patients who underwent lung transplantation surgery from 2010–2019. Results are stratified by recipient development of mollicute infection after transplant. Univariate associations between each variable and prevalence of recipient mollicute infection were assessed with log-binomial regression.
| Donor Characteristic, n (%) | Recipient Mollicute Infection (N=27) | No Recipient Mollicute Infection (N=1,129) | PRR for Recipient Mollicute Infection (95% CI) | P value |
|---|---|---|---|---|
| Age ≤40 years | 22 (81.5) | 675 (59.8) | 2.9 (1.1–7.6) | .03 |
| Male sex | 20 (74.1) | 696 (61.6) | 1.8 (0.7–4.1) | .20 |
| Race/ethnicity | ||||
| White | 23 (85.2) | 722 (64.0) | 3.2 (1.1–9.1) | .03 |
| Black | 2 (7.4) | 256 (22.7) | 0.3 (0.1–1.2) | .08 |
| Hispanic | 1 (3.7) | 83 (7.4) | 0.5 (0.1–3.6) | .48 |
| Othera | 1 (3.7) | 68 (6.0) | 0.6 (0.1–4.4) | .62 |
| Obese (BMI >30 kg/m2) | 5 (18.5) | 269 (23.8) | 0.7 (0.3–1.9) | .52 |
| Underweight (BMI <20 kg/m2) | 1 (3.7) | 87 (7.7) | 0.5 (0.1–3.4) | .45 |
| Diabetes mellitusb | 2 (7.4) | 101 (8.9) | 0.8 (0.2–3.4) | .78 |
| Renal insufficiency (creatinine ≥1.3) | 10 (37.0) | 368 (32.6) | 1.2 (0.6–2.6) | .63 |
| PHS increased risk donor c | 11 (40.7) | 239 (21.2) | 2.5 (1.2–5.3) | .02 |
| Heavy alcohol used | 5 (19.2) | 168 (15.2) | 1.3 (0.5–3.4) | .57 |
| Death due to anoxia | 13 (48.1) | 275 (24.4) | 2.8 (1.3–5.9) | .01 |
| Abnormal chest X-raye | 18 (66.7) | 762 (67.7) | 1.0 (0.4–2.1) | .91 |
| Purulent secretions on bronchoscopy f | 10 (37.0) | 217 (19.2) | 2.4 (1.1–5.2) | .02 |
Data are presented as No. (%) unless otherwise indicated.
Abbreviations: BMI, body mass index; CI, confidence interval; N/A, not applicable; PHS, Public Health Service; PRR, prevalence rate ratio.
Other race/ethnicity for donor associated with recipient mollicute infection was reported as multiracial. Other race/ethnicity for donors not associated with recipient mollicute infection was reported as multiracial (n=45), Asian (n=22), or American Indian/Alaska native (n=1).
Diabetes mellitus was considered not to be present for 9 (0.8%) donors for whom diabetes status was not documented. These donors were not associated with recipient mollicute infection.
Donor at increased risk for human immunodeficiency virus, hepatitis B virus, or hepatitis C virus transmission to recipient, according to the United States Public Health Service guideline recommendations.23
Data on heavy alcohol use were excluded for 25 (2.2%) donors with unknown alcohol use histories. These donors included 1 donor associated with recipient mollicute infection and 24 donors not associated with recipient mollicute infection.
Data on chest x-ray findings were excluded for 4 (0.3%) donors without reported chest X-ray findings. These donors were not associated with recipient mollicute infection.
As documented at time of procurement. Secretions were considered not to be purulent for 43 (3.7%) donors for whom bronchoscopy findings were not documented. These donors included 2 donors associated with recipient mollicute infection and 41 donors not associated with recipient mollicute infection.