Table 1.
Zonated mitochondrial phosphoproteins, phosphosites, and cellular function
| Protein | P-Zonation | P-site | Function |
|---|---|---|---|
| Acaca | PP | S29a | Lipogenesis |
| Akap1 | PP | S101/S103b/S104/S109 | cAMP-PKA signaling |
| Apex1 | PP | S18 | mtDNA maintenance |
| Bcl2l13 | PP | S387 | Mitophagy |
| Bnip3 | PP | S79, S85, S88b, T66b | Mitophagy |
| Comt | PP | S261 | Catechol metabolism |
| Ehhadh | PP | T543 | Fatty acid oxidation |
| Gpam | PP | S687, S694 | Phospholipid metabolism |
| Mtfr1 | PP | T118 | Fission |
| Mtfr1l | PP | S234/S235b | Fission |
| Nadk2 | PP | S373 | Phosphorylation of NAD |
| Prkaca | PP | T198b | cAMP-PKA signaling |
| Rmdn3 | PP | S46b, S50 | Mito dynamics/contact sites |
| Slirp | PP | S105 | mtRNA stability |
| Tfam | PP | S241 | mtDNA maintenance |
| Tomm70 | PP | S94a | Protein import and sorting |
| Akap1 | PC | T487 | cAMP-PKA signaling |
| Bckdk | PC | S31b | Amino acid metabolism |
| Bnip3 | PC | S60b | Mitophagy |
| Coq9 | PC | S81 | Coenzyme Q metabolism |
| Gpam | PC | S694 | Phospholipid metabolism |
| Hsd17b8 | PC | S58 | Lipid biosynthesis |
| Kars1 | PC | S594 | Protein translation |
| Miga2 | PC | S276 | Fusion/contact sites |
| Mrps36 | PC | S55/T59/S60 | Mitochondrial translation |
| Mtif2 | PC | S180 | Protein translation |
| Nags | PC | S44 | Amino acid metabolism |
| Nsun2 | PC | S23 | RNA modification |
| Pdha1 | PC | S293a, S300a | Pyruvate metabolism |
| Tomm22 | PC | S45 | Protein import and sorting |
Dash and comma distinguish between potential and identified phosphosites, respectively.
PP periportal, PC pericentral.
aInhibitory.
bActivating phosphosites.