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. 2023 Jul 21;28(5):e17855. doi: 10.1111/jcmm.17855

FIGURE 4.

FIGURE 4

FLRT2 overexpression promotes ferroptosis of human bladder cancer cells. (A) KEGG analysis of the top five pathways altered in FLRT2‐silenced T24 cells (n = 3 or 6). (B) LDH releases were measured to evaluate cell death (n = 6). (C, D) ROS generation and lipid peroxidation in FLRT2‐overexpressed or CTRL human bladder cancer cells (n = 6). (E, F) Levels of 12/15‐HETEs in cell medium (n = 6). (G) Levels of ferrous iron (n = 6). (H, I) Levels of GSH and GPX4 activity in FLRT2‐overexpressed or CTRL human bladder cancer cells (n = 6). All data are presented as the mean ± SD, p < 0.05 was considered statistically significant. NS indicates no significance.