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. 2023 Aug 8;32(2):192–204. doi: 10.4062/biomolther.2023.118

Table 3.

Summary of the volatile general anesthetics modulating TRP channels

VGAs TRPA1 TRPV1 TRPM3 TRPM8 TRPC5
Effects: CGRP release, respiratory inhibition Effects: CGRP release, hyperthermia Effects: Hypothermia respiratory inhibition
Isoflurane graphic file with name bt-32-2-192-tf10.jpg Activation Enhancement Activation (Inhibition by prolonged exposure)
Desflurane graphic file with name bt-32-2-192-tf11.jpg Activation Enhancement Activation (Inhibition by prolonged exposure)
Sevoflurane graphic file with name bt-32-2-192-tf12.jpg Enhancement Inhibition Activation (Inhibition by prolonged exposure)
Halothane graphic file with name bt-32-2-192-tf13.jpg Activation Inhibition Activation (Inhibition by prolonged exposure) Inhibition
Chloroform graphic file with name bt-32-2-192-tf14.jpg Inhibition Inhibition