Table 2. AML risk status based on cytogenetics and molecular abnormalities.

Complex karyotype refers to three or more chromosomal abnormalities [6-8].

Risk Status	Cytogenetics	Molecular
Low/Favorable	inv(16), t(16;16), t(8;21), t(15;17)	NPM1 (FLT3-ITD neg.), CEBPA
Intermediate	Normal cytogenetics, trisomy 8, t(9;11)	-
High/Poor	Complex karyotype, -5/5q-, -7/7q-, 11q23-, inv(3), t(3;3), t(6;9), t(9;22)	TP53, RUNX1, ASXL1, FLT3-ITD