Table 4.
Mediators in the association between tuberculosis and any psychotic experience*
| Mediator | Total effect, OR (95%CI) | P-value | Direct effect, OR (95%CI) | P-value | Indirect effect, OR (95%CI) | P-value | Mediated % |
|---|---|---|---|---|---|---|---|
| Affect |
2.29 (1.89–2.77) |
<0.001 |
1.76 (1.45–2.13) |
<0.001 |
1.30 (1.22–1.38) |
<0.001 |
31.5 |
| Cognition |
2.32 (1.94–2.77) |
<0.001 |
1.99 (1.66–2.39) |
<0.001 |
1.16 (1.12–1.21) |
<0.001 |
17.9 |
| Interpersonal activities |
2.32 (1.94–2.78) |
<0.001 |
2.17 (1.81–2.59) |
<0.001 |
1.07 (1.04–1.10) |
<0.001 |
8.3 |
| Mobility |
2.34 (1.95–2.80) |
<0.001 |
2.06 (1.72–2.48) |
<0.001 |
1.13 (1.09–1.17) |
<0.001 |
14.6 |
| Pain/discomfort |
2.35 (1.96–2.81) |
<0.001 |
1.92 (1.60–2.31) |
<0.001 |
1.22 (1.17–1.27) |
<0.001 |
23.5 |
| Perceived stress† |
2.12 (1.74–2.58) |
<0.001 |
1.93 (1.59–2.36) |
<0.001 |
1.09 (1.05–1.14) |
<0.001 |
12.0 |
| Self-care |
2.32 (1.94–2.77) |
<0.001 |
2.18 (1.82–2.61) |
<0.001 |
1.06 (1.04–1.09) |
<0.001 |
7.4 |
| Sleep/energy |
2.32 (1.93–2.78) |
<0.001 |
1.83 (1.53–2.20) |
<0.001 |
1.26 (1.20–1.32) |
<0.001 |
27.8 |
| All mediators† | 1.97 (1.60–2.42) | <0.001 | 1.39 (1.13–1.71) | 0.002 | 1.41 (1.31–1.52) | <0.001 | 50.8 |
CI – confidence interval, OR – odds ratio
*Any psychotic experience referred to having at least one delusional mood, delusions of reference, and persecution, delusions of control, and hallucinations in the past 12 mo. Models are adjusted for age, sex, wealth, education, setting, diabetes, smoking, alcohol consumption, and country.
†Data were not available from Brazil, Hungary, and Zimbabwe.