Fig. 1.

Widespread significant associations of conventional DTI metrics (MD and FA) with age across the WM skeleton. Age associations are largely positive for MD and negative for FA, although certain medial WM regions have no or positive age associations of FA. Note that the contrast is the difference in metric per year derived from a linear regression and displayed only in voxels with significant correlations with age. Voxels of the WM skeleton without significant correlations with age are displayed in white. Abbreviations: DTI, diffusion tensor imaging; MD, mean diffusivity; FA, fractional anisotropy; WM, white matter.