Table 2.

Animal, Demographic, IOP, Global OCT EG Eye RNFLT Loss and Global Orbital Optic Nerve Axon Alterations at Euthanasia

Animal#	Sex	Age at Euthanasia, y (mo)	Weight (kg)	Eye	EG or C	Baseline Mean IOP* (mm Hg)	Postlaser Mean IOP (mm Hg)	Postlaser Peak IOP (mm Hg)	IOP at Euthanasia† (mm Hg)	EG Eye: Cumulative IOP Insult‡ (mm Hg/d)	EG Eye: Global % RNFLT Loss at Euthanasia§(mm)	Global Axon Counts	EG vs. C: Global % Axon Count Difference (EG – C)/C	EG vs. C: Global % Axon Density Difference (EG – C)/C	EG vs. C: Global % Axon Size Difference (EG – C)/C
NHP1	M	3 (5)	6.8	OD	EG	11.66	30.54	44.6	23.67	994	31.2 | 31.4	578,105	−54.1	−53.4	−31.2
				OS	C	9.44	11.12	14.6	9.3			1,259,345
NHP2	M	24 (6)	12.3	OD	EG	12.88	17.03	30	16	415.8	11.1 | 9.5	1,082,035	−10.9	−16.4	6.5
				OS	C	12.95	12.15	14.3	13			1,214,938
NHP3	F	3 (3)	5.7	OS	EG	11.11	13.31	20	7.67	150.3	5 | 4.6	1,064,966	−5.5	1.6	−14.7
				OD	C	11.88	12.2	16.3	8			1,126,698

C, control; F, female; M, male.

^*Baseline mean IOP C/EG (mm Hg): average of all prelaser IOP measurements.

^†IOP at euthanasia: IOP on necropsy table prior to sacrifice.

^‡Cumulative IOP insult: difference between EG versus C eye area under the postlaser IOP curves expressed in mm Hg × days.

^§EG eye % RNFLT loss at euthanasia: data are EG/C at euthanasia (left) and EG eye at euthanasia / EG eye at baseline (right).