Table 2.
The signaling pathways involved differentially expressed genes in Pathway at each time point compared with the first day after operation
| Up | P value | Down | P value |
|---|---|---|---|
| Day4 vs. Day1 | |||
| Proteoglycans BR | 8.73E-08 | Measles | 3.18E-17 |
| Cell cycle | 9.58E-07 | Influenza A | 2.13E-14 |
| DNA replication proteins BR | 3.65E-06 | Chemokine signaling pathway | 5.46E-13 |
| ECM-receptor interaction | 4.80E-06 | C-type lectin receptor signaling pathway | 7.05E-13 |
| PI3K-Akt signaling pathway | 1.16E-05 | Leishmaniasis | 1.90E-12 |
| Rap1 signaling pathway | 3.01E-05 | Osteoclast differentiation | 4.71E-12 |
| Glycosaminoglycan binding proteins BR | 1.40E-04 | NOD-like receptor signaling pathway | 1.26E-11 |
| Focal adhesion | 2.45E-04 | Epstein-Barr virus infection | 1.62E-11 |
| Hypertrophic cardiomyopathy (HCM) | 3.12E-04 | NF-kappa B signaling pathway | 2.16E-11 |
| Dilated cardiomyopathy (DCM) | 4.47E-04 | Toll-like receptor signaling pathway | 2.61E-11 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 7.47E-04 | B cell receptor signaling pathway | 4.71E-10 |
| Axon guidance | 1.03E-03 | FoxO signaling pathway | 6.59E-10 |
| Regulation of actin cytoskeleton | 2.03E-03 | Tuberculosis | 1.70E-09 |
| Hippo signaling pathway-multiple species | 2.82E-03 | Kaposi sarcoma-associated herpesvirus infection | 1.86E-09 |
| Hippo signaling pathway | 3.09E-03 | Pattern recognition receptors BR | 2.47E-09 |
| Oocyte meiosis | 3.70E-03 | CD molecules BR | 4.93E-09 |
| Cytoskeleton proteins BR | 5.38E-03 | Hepatitis B | 8.85E-09 |
| Chromosome and associated proteins BR | 5.49E-03 | Fc epsilon RI signaling pathway | 1.08E-08 |
| Protein kinases BR | 7.56E-03 | MAPK signaling pathway | 9.79E-08 |
| Gap junction | 9.15E-03 | Toxoplasmosis | 1.00E-07 |
| Day7 vs. Day1 | |||
| Proteoglycans BR | 2.06E-08 | Measles | 2.78E-16 |
| Axon guidance | 1.40E-06 | Influenza A | 1.11E-15 |
| Rap1 signaling pathway | 6.69E-06 | Chemokine signaling pathway | 2.05E-15 |
| Cell cycle | 1.02E-05 | C-type lectin receptor signaling pathway | 5.43E-15 |
| PI3K-Akt signaling pathway | 4.74E-05 | Toll-like receptor signaling pathway | 4.91E-14 |
| Focal adhesion | 5.01E-05 | Osteoclast differentiation | 1.26E-13 |
| ECM-receptor interaction | 9.84E-05 | NF-kappa B signaling pathway | 3.58E-13 |
| Hippo signaling pathway-multiple species | 2.19E-04 | B cell receptor signaling pathway | 4.97E-13 |
| DNA replication proteins BR | 2.30E-04 | Epstein-Barr virus infection | 6.56E-12 |
| Chromosome and associated proteins BR | 8.06E-04 | NOD-like receptor signaling pathway | 6.69E-12 |
| Regulation of actin cytoskeleton | 9.21E-04 | Leishmaniasis | 9.54E-12 |
| Pathways in cancer | 9.93E-04 | CD molecules BR | 1.30E-11 |
| Glycosaminoglycan binding proteins BR | 1.73E-03 | Hepatitis B | 1.76E-11 |
| Ras signaling pathway | 2.74E-03 | MAPK signaling pathway | 2.71E-11 |
| Dilated cardiomyopathy (DCM) | 2.76E-03 | Toxoplasmosis | 1.04E-10 |
| Hypertrophic cardiomyopathy (HCM) | 5.12E-03 | Pattern recognition receptors BR | 2.77E-10 |
| Protein kinases BR | 5.27E-03 | Kaposi sarcoma-associated herpesvirus infection | 8.03E-10 |
| N-Glycan biosynthesis | 6.32E-03 | Cytokine receptors BR | 4.36E-09 |
| Gap junction | 6.61E-03 | FoxO signaling pathway | 8.27E-09 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 7.05E-03 | T cell receptor signaling pathway | 1.18E-08 |
| Day9 vs. Day1 | |||
| Proteoglycans BR | 1.99E-08 | Measles | 9.22E-17 |
| Rap1 signaling pathway | 5.52E-07 | Influenza A | 1.26E-15 |
| Focal adhesion | 6.91E-07 | Osteoclast differentiation | 3.31E-15 |
| ECM-receptor interaction | 3.10E-06 | Chemokine signaling pathway | 3.19E-14 |
| Axon guidance | 5.16E-06 | NF-kappa B signaling pathway | 1.52E-13 |
| PI3K-Akt signaling pathway | 1.39E-05 | B cell receptor signaling pathway | 1.70E-13 |
| Dilated cardiomyopathy (DCM) | 6.13E-05 | C-type lectin receptor signaling pathway | 1.93E-13 |
| Hypertrophic cardiomyopathy (HCM) | 1.45E-04 | Toll-like receptor signaling pathway | 2.76E-13 |
| Ribosome | 1.65E-04 | Leishmaniasis | 3.51E-13 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 2.51E-04 | NOD-like receptor signaling pathway | 7.41E-13 |
| Glycosaminoglycan binding proteins BR | 3.68E-04 | Epstein-Barr virus infection | 2.31E-11 |
| Gap junction | 5.99E-04 | Hepatitis B | 2.52E-11 |
| Ribosome BR | 7.88E-04 | Tuberculosis | 1.72E-10 |
| Cytoskeleton proteins BR | 8.77E-04 | CD molecules BR | 4.05E-10 |
| Hippo signaling pathway-multiple species | 1.33E-03 | Toxoplasmosis | 8.41E-10 |
| Regulation of actin cytoskeleton | 1.94E-03 | T cell receptor signaling pathway | 1.07E-09 |
| Progesterone-mediated oocyte maturation | 1.99E-03 | FoxO signaling pathway | 1.18E-09 |
| Ras signaling pathway | 2.37E-03 | Acute myeloid leukemia | 1.37E-09 |
| Pathways in cancer | 2.42E-03 | Kaposi sarcoma-associated herpesvirus infection | 1.77E-09 |
| Vascular smooth muscle contraction | 2.71E-03 | TNF signaling pathway | 2.60E-09 |
| Day11 vs. Day1 | |||
| Rap1 signaling pathway | 4.86E-09 | Influenza A | 6.08E-17 |
| ECM-receptor interaction | 2.86E-08 | B cell receptor signaling pathway | 3.96E-16 |
| Proteoglycans BR | 6.35E-08 | Measles | 1.73E-15 |
| Focal adhesion | 8.74E-07 | Osteoclast differentiation | 7.86E-15 |
| PI3K-Akt signaling pathway | 1.08E-06 | Chemokine signaling pathway | 2.15E-14 |
| Axon guidance | 3.97E-06 | Toll-like receptor signaling pathway | 4.91E-14 |
| Glycosaminoglycan binding proteins BR | 4.35E-06 | Leishmaniasis | 8.77E-13 |
| Pathways in cancer | 1.06E-05 | Apoptosis | 1.23E-12 |
| Gap junction | 1.73E-05 | NOD-like receptor signaling pathway | 5.36E-12 |
| Platelet activation | 2.25E-04 | T cell receptor signaling pathway | 7.33E-12 |
| Progesterone-mediated oocyte maturation | 2.83E-04 | Epstein-Barr virus infection | 1.33E-11 |
| Dilated cardiomyopathy (DCM) | 3.55E-04 | NF-kappa B signaling pathway | 1.39E-11 |
| Relaxin signaling pathway | 3.94E-04 | Hepatitis B | 1.89E-11 |
| Wnt signaling pathway | 5.01E-04 | C-type lectin receptor signaling pathway | 2.09E-11 |
| Human papillomavirus infection | 6.00E-04 | Fc epsilon RI signaling pathway | 3.46E-11 |
| Hypertrophic cardiomyopathy (HCM) | 8.88E-04 | Acute myeloid leukemia | 3.46E-11 |
| Cell cycle | 9.55E-04 | FoxO signaling pathway | 1.50E-10 |
| Fluid shear stress and atherosclerosis | 1.26E-03 | TNF signaling pathway | 1.61E-10 |
| Vascular smooth muscle contraction | 2.10E-03 | Tuberculosis | 4.67E-10 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 2.25E-03 | Kaposi sarcoma-associated herpesvirus infection | 1.25E-09 |
| Day14 vs. Day1 | |||
| Focal adhesion | 6.42E-09 | Measles | 1.91E-17 |
| Axon guidance | 2.79E-08 | Chemokine signaling pathway | 4.74E-17 |
| Rap1 signaling pathway | 4.94E-08 | CD molecules BR | 4.26E-16 |
| ECM-receptor interaction | 7.32E-08 | C-type lectin receptor signaling pathway | 1.76E-15 |
| PI3K-Akt signaling pathway | 1.44E-07 | Influenza A | 3.03E-15 |
| Hypertrophic cardiomyopathy (HCM) | 3.41E-06 | Epstein-Barr virus infection | 5.34E-15 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 3.67E-06 | NF-kappa B signaling pathway | 1.61E-14 |
| Pathways in cancer | 5.74E-06 | Leishmaniasis | 6.16E-14 |
| Dilated cardiomyopathy (DCM) | 6.01E-06 | Toll-like receptor signaling pathway | 1.03E-13 |
| Proteoglycans BR | 2.11E-05 | B cell receptor signaling pathway | 1.09E-13 |
| Vascular smooth muscle contraction | 4.63E-05 | NOD-like receptor signaling pathway | 2.05E-13 |
| Glycosaminoglycan binding proteins BR | 4.73E-05 | Osteoclast differentiation | 1.43E-12 |
| Regulation of actin cytoskeleton | 1.23E-04 | Kaposi sarcoma-associated herpesvirus infection | 9.96E-12 |
| cGMP-PKG signaling pathway | 1.63E-04 | T cell receptor signaling pathway | 3.43E-11 |
| Hippo signaling pathway | 2.38E-04 | Pattern recognition receptors BR | 5.83E-11 |
| Gap junction | 2.62E-04 | Tuberculosis | 1.09E-10 |
| Adherens junction | 3.45E-04 | Toxoplasmosis | 2.02E-10 |
| Relaxin signaling pathway | 3.93E-04 | FoxO signaling pathway | 2.19E-10 |
| Ras signaling pathway | 4.18E-04 | Fc epsilon RI signaling pathway | 2.40E-10 |
| Hippo signaling pathway-multiple species | 5.45E-04 | Hepatitis B | 6.48E-10 |
| Day28 vs. Day1 | |||
| Proteoglycans BR | 2.22E-10 | Measles | 6.65E-16 |
| PI3K-Akt signaling pathway | 3.95E-10 | CD molecules BR | 6.89E-14 |
| Axon guidance | 5.30E-10 | Chemokine signaling pathway | 1.74E-13 |
| Rap1 signaling pathway | 3.20E-09 | Toll-like receptor signaling pathway | 1.84E-12 |
| Focal adhesion | 1.32E-08 | Osteoclast differentiation | 2.52E-12 |
| ECM-receptor interaction | 2.26E-07 | Epstein-Barr virus infection | 2.96E-12 |
| Adherens junction | 1.11E-06 | NF-kappa B signaling pathway | 6.02E-12 |
| Glycosaminoglycan binding proteins BR | 1.47E-06 | Influenza A | 6.45E-12 |
| Dilated cardiomyopathy (DCM) | 9.22E-06 | Leishmaniasis | 1.46E-11 |
| Pathways in cancer | 1.07E-05 | Tuberculosis | 6.92E-11 |
| Ras signaling pathway | 2.33E-05 | C-type lectin receptor signaling pathway | 1.54E-10 |
| Wnt signaling pathway | 4.07E-05 | NOD-like receptor signaling pathway | 1.75E-10 |
| cGMP-PKG signaling pathway | 4.95E-05 | Pattern recognition receptors BR | 2.59E-10 |
| Phospholipase D signaling pathway | 1.03E-04 | B cell receptor signaling pathway | 4.06E-10 |
| Glycosaminoglycan biosynthesis-keratan sulfate | 1.27E-04 | Fc epsilon RI signaling pathway | 8.81E-09 |
| Relaxin signaling pathway | 2.37E-04 | Cytokine receptors BR | 1.40E-08 |
| Proteoglycans in cancer | 5.03E-04 | T cell receptor signaling pathway | 2.28E-08 |
| Regulation of actin cytoskeleton | 5.09E-04 | TNF signaling pathway | 4.57E-08 |
| Hypertrophic cardiomyopathy (HCM) | 5.47E-04 | Jak-STAT signaling pathway | 4.57E-08 |
| Hippo signaling pathway | 6.13E-04 | MAPK signaling pathway | 9.17E-08 |