Fig. 1.

Schematic representation of a single Kv7.2 subunit, alignment and functional analysis of mutations at position Y141 and G239. A. Cartoon depicting the six transmembrane arrangement of a single Kv7.2 subunit (left panel) and sequence alignments of the S2 and S5 (right panel) regions among different Kv subunits. B. Macroscopic currents from Kv7.2, Kv7.2 Y141N and Kv7.2 G239S channels, in response to the indicated voltage protocol. Current scale, 200 ​pA; time scale, 200 ​ms. C. Current density from currents from Kv7.2, Kv7.2 Y141N and Kv7.2 G239S channels calculated at 0 ​mV. D. Conductance/voltage curves for the indicated channels. Continuous lines are Boltzmann fits to the experimental data.