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Effect of amitriptyline on heteromeric channels incorporating Kv7.2 mutant subunits. A. Representative current traces in response to the voltage ramp protocol before and during amitriptyline (AMI) exposure (1 and 10 μM) from cells expressing the indicated subunit combinations. Current scale, 200 pA; time scale, 200 ms. B. % of current inhibition upon amitriptyline application.∗ indicate values significantly different from each respective control (p < 0.05).
