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. 2023 Dec 19;21(1):e00296. doi: 10.1016/j.neurot.2023.10.006

Table 1.

Biophysical and pharmacological properties of mutant Kv7.2 channels.

Blockade by amitriptyline (%)
Construct(s) n Half-activation potential, V½ (mV) Slope factor, k (mV/e-fold) Current density (pA/pF) 1 ​μM 10 ​μM
Kv7.2 28 −22.3 ​± ​0.9 12.6 ​± ​0.6 26.9 ​± ​3.2
Kv7.2 Y141N 22 −35.4 ​± ​0.6∗ 14.9 ​± ​0.6∗ 50.1 ​± ​6.4∗
Kv7.2 G239S 16 −30.5 ​± ​1.7∗ 14.3 ​± ​0.7∗ 38.2 ​± ​5.5∗
Kv7.2 + Kv7.3 10 −27.1 ​± ​1.0 10.6 ​± ​0.5 112.4 ​± ​15.1 8.1 ​± ​1.2 40.0 ​± ​3.8
Kv7.2 + Kv7.2 Y141N
+ Kv7.3
13 −28.7 ​± ​1.1 11.3 ​± ​0.6 99.9 ​± ​17.0 9.7 ​± ​2.5 39.8 ​± ​3.0
Kv7.2 + Kv7.2 G239S
+ Kv7.3
11 −28.7 ​± ​1.6 13.9 ​± ​1.0 135.5 ​± ​30.4 11.8 ​± ​3.6 64.6 ​± ​5.2∗∗

∗p ​< ​0.05 versus Kv7.2; ∗∗p ​< ​0.05 versus Kv7.2+Kv7.3.