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Genetic suppressors of the temperature-sensitive Srb4-138 mutant RNA polymerase II holoenzyme. Conditional defects in the essential Srb4 subunit of the holoenzyme might be overcome by compensatory gain-of-function mutations in a general positive regulator or loss-of-function mutations in a global negative regulator. RNAPII and RNA polII, RNA polymerase II; CTD, C-terminal domain; ts, temperature sensitive.
