Table 3.
Regression results for clinical/demographic and acute cognitive factors predictive of follow-up impairment.
| Proportion of OCS subtests impaired at 6 months | |||
|---|---|---|---|
| Block 1: Demographic/clinical factors | β (SE) | t | p |
| Age | 0.094 (0.001) | 4.817 | 0.000* a |
| Sex (male) | −0.006 (0.026) | −0.222 | 0.825 |
| Education | −0.009 (0.004) | −2.527 | 0.012* |
| Atrial fibrillation | −0.025 (0.030) | −0.847 | 0.398 |
| Hypertension | −0.031 (0.026) | −1.182 | 0.238 |
| Diabetes | 0.041 (0.031) | 1.325 | 0.186 |
| Smoking | 0.073 (0.032) | 2.241 | 0.026* |
| NIHSS | 0.004 (0.003) | 1.372 | 0.171 |
| Recurrent stroke | 0.045(0.032) | 1.646 | 0.107 |
| Days to assessment | 0.001 (0.003) | 0.476 | 0.635 |
| Lesion volume | <0.001 (<0.001) | 2.923 | 0.004* |
| R2 = 0.134, Adjusted R2 = 0.105, F = 4.693, 11 and 333 df, p < 0.0001 | |||
| Block 2 (Model 1): Proportion of acute subtests impaired |
β (SE) | t | p |
| Age | 0.005 (0.001) | 4.674 | 0.000* a |
| Sex (male) | −0.004 (0.023) | −0.197 | 0.844 |
| Education years | −0.005 (0.003) | −1.527 | 0.128 |
| Atrial fibrillation | −0.032 (0.026) | −1.223 | 0.222 |
| Hypertension | −0.033 (0.023) | −1.452 | 0.147 |
| Diabetes | −0.006 (0.028) | −0.213 | 0. 831 |
| Smoking | 0.006 (0.029) | 2.066 | 0.040* |
| NIHSS | −0.000 (0.002) | −0.134 | 0.893 |
| Recurrent stroke | 0.045 (0.024) | 1.862 | 0.064 |
| Days to assessment | 0.002 (0.003) | 0.786 | 0.433 |
| Lesion volume | <0.001 (<0.001) | 1.132 | 0.2585 |
| Severity of acute cognitive impairment | 0.403 (0.042) | 9.616 | 0.000* a |
| R2 = 0.323, Adjusted R2 = 0.298, F = 13.190, 12 and 332 df, p < 0.0001 | |||
| Block 2 (Model 2): Acute domain-specific impairment |
β (SE) | t | p |
| Age | 0.004 (0.001) | 4.266 | 0.000* a |
| Sex (male) | 0.009 (0.023) | 0.399 | 0.690 |
| Education years | −0.005 (0.003) | −1.475 | 0.141 |
| Atrial fibrillation | −0.027 (0.026) | −1.040 | 0.299 |
| Block 2 (Model 2): Acute domain-specific impairment |
β (SE) | t | p |
| Hypertension | −0.027 (0.023) | −1.182 | 0.238 |
| Diabetes | −0.003 (0.029) | −0.094 | 0.925 |
| Smoking | 0.076 (0.029) | 2.618 | 0.009* |
| NIHSS | 0.001 (0.002) | 0.529 | 0.597 |
| Recurrent stroke | 0.039 (0.024) | 1.619 | 0.107 |
| Days to assessment | 0.000 (0.003) | 0.155 | 0.877 |
| Lesion volume | 0.000 (0.000) | 0.715 | 0.475 |
| Language | 0.095 (0.027) | 4.303 | 0.000* a |
| Attention | 0.011 (0.024) | 0.446 | 0.656 |
| Executive | 0.065 (0.027) | 2.376 | 0.018* |
| Memory | 0.116 (0.027) | 4.303 | 0.000* a |
| Number | 0.041 (0.028) | 1.477 | 0.141 |
| Praxis | 0.084 (0.028) | 3.042 | 0.002* a |
| R2 = 0.345, Adjusted R2 = 0.309, F = 9.612, 167 and 310 df, p < 0.0001 | |||
OCS: Oxford Cognitive Screen; NIHSS: National Institute of Health Stroke Scale.
a
Remained significant after Bonferroni correction for multiple comparisons.
*
Significance p < 0.05.