Table 2.
The causal effect of psychiatric disorders on OSA.
| Exposure | Method | nSNPs | OR | 95% CI | P-value | Heterogeneity | Pleiotropy | |
|---|---|---|---|---|---|---|---|---|
| Q_P-value | Egger intercept P-value | MR-PRESSO P-value | ||||||
| MDD | IVW | 41 | 1.377 | 1.242-1.526 | 1.05×10-9 | 0.084 | 0.114 | |
| MR-Egger | 41 | 1.104 | 0.597-2.041 | 0.754 | 0.078 | 0.480 | ||
| Weighted median | 41 | 1.301 | 1.135-1.491 | 1.576×10-4 | ||||
| Weighted mode | 41 | 1.253 | 0.911-1.724 | 0.173 | ||||
| ANX | IVW | 6 | 1.017 | 0.979-1.056 | 0.397 | 0.482 | 0.509 | |
| MR-Egger | 6 | 0.977 | 0.872-1.095 | 0.709 | 0.411 | 0.508 | ||
| Weighted median | 6 | 0.991 | 0.939-1.045 | 0.729 | ||||
| Weighted mode | 6 | 0.987 | 0.923-1.057 | 0.730 | ||||
| BIP | IVW | 38 | 1.016 | 0.974-1.063 | 0.434 | 0.342 | 0.343 | |
| MR-Egger | 38 | 0.959 | 0.732-1.256 | 0.763 | 0.308 | 0.665 | ||
| Weighted median | 38 | 0.992 | 0.935-1.053 | 0.780 | ||||
| Weighted mode | 38 | 0.987 | 0.876-1.114 | 0.838 | ||||
| SCZ | IVW | 137 | 1.017 | 0.992-1.043 | 0.175 | 0.035 | 0.037 | |
| MR-Egger | 137 | 0.946 | 0.852-1.051 | 0.303 | 0.041 | 0.165 | ||
| Weighted median | 137 | 0.997 | 0.964-1.032 | 0.884 | ||||
| Weighted mode | 137 | 0.926 | 0.822-1.044 | 0.211 | ||||
| PTSD | IVW | 20 | 1.032 | 0.985-1.081 | 0.189 | 0.042 | 0.052 | |
| MR-Egger | 20 | 1.070 | 0.980-1.168 | 0.150 | 0.044 | 0.352 | ||
| Weighted median | 20 | 1.031 | 0.971-1.096 | 0.320 | ||||
| Weighted mode | 20 | 1.057 | 0.982-1.137 | 0.159 | ||||
MDD, major depressive disorder; SCZ, schizophrenia; BIP, bipolar disorder; ANX, anxiety disorder; PTSD, post-traumatic stress disorder; OSA, obstructive sleep apnea; BMI, body mass index; nSNPs, number of single-nucleotide polymorphisms; IVW, inverse-variance weighted; OR, odds ratio; CI, confidence interval; MR, Mendelian randomization; MR-PRESSO, MR pleiotropy residual sum and outlier.