Table 3.
Results of multivariable MR analysis.
| Exposure | Outcome | Method | OR | 95% CI | P-value |
|---|---|---|---|---|---|
| Adjusted for BMI | OSA | IVW | 1.136 | 1.005-1.284 | 0.041 |
| MR-Egger | 1.338 | 1.106-1.618 | 2.67×10-3 | ||
| MR-Lasso | 1.167 | 1.056-1.288 | 2.33×10-3 | ||
| Adjusted for smoking | OSA | IVW | 1.337 | 1.157-1.544 | 8.06×10-5 |
| MR-Egger | 1.270 | 1.016-1.586 | 0.036 | ||
| MR-Lasso | 1.407 | 1.263-1.566 | 4.84×10-10 | ||
| Adjusted for alcohol consumption | OSA | IVW | 1.298 | 1.133-1.487 | 1.71×10-4 |
| MR-Egger | 1.651 | 1.247-2.185 | 4.58×10-4 | ||
| MR-Lasso | 1.312 | 1.189-1.449 | 6.82×10-8 |
OSA, obstructive sleep apnea; BMI, body mass index; OR, odds ratio; CI, confidence interval; IVW, inverse-variance weighted.