Table 2.

Predicting the performance of sNFL measurements for disease activity in the past 90 days (from day −90 to day 0).

sNFL measure	Any activity (radiographic or relapse) 51/726 events in 34/124 subjects	Radiographic activity (GEL/T2) 40/726 events in 27/124 subjects	GEL activity 22/726 events in 17/124 subjects	T2 activity 39/726 events in 27/124 subjects	Relapse 24/726 events in 19/124 subjects
log(sNFL)	AIC = 352.90	AIC = 303.52	AIC = 196.18	AIC = 298.68	AIC = 199.66
	AUC = 0.72	AUC = 0.68	AUC = 0.69	AUC = 0.68	AUC = 0.77
	p < 0.0001	p = 0.0015	p = 0.0254	p = 0.0023	p = 0.0001
log(sNFL) + age	AIC = 351.91	AIC = 300.79	AIC = 195.96	AIC = 296.75	AIC = 199.27
	AUC = 0.72	AUC = 0.67	AUC = 0.69	AUC = 0.67	AUC = 0.78
	p < 0.0001	p = 0.0006	p = 0.0272	p = 0.0014	p = 0.0002
sNFL Z-score	AIC = 345.75	AIC = 297.26	AIC = 191.41	AIC = 293.22	AIC = 193.00
	AUC = 0.72	AUC = 0.69	AUC = 0.70	AUC = 0.69	AUC = 0.77
	p < 0.0001	p = 0.0001	p = 0.0018	p = 0.0001	p < 0.0001