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. 2022 Mar 17;3(1):011306. doi: 10.1063/5.0080512

FIG. 5.

FIG. 5.

Coupled dynamics of EMT and PAGE4 circuits containing IDPs. (a) Coupled network of EMT and PAGE4 circuit. Solid red hammer heads correspond to transcriptional inhibition, and dotted red hammer heads correspond to post transcriptional inhibition due to micro-RNA interaction. Solid black arrows correspond to transcriptional activation, and dotted arrows stand for phosphorylation. (b) and (c) Dynamics of AR: AR levels over time for two different values of interaction strength with ZEB. (d) Induction of EMT via SNAI1 leads to oscillations converting to bistability. Phase plot between interaction strengths of AR and Zeb, as EMT is induced via SNAI1, Zeb inhibits AR more strongly and leads to oscillations converting to bistability. [Adapted from Singh et al., Entropy (Basel) 23(3), 288 (2021). Copyright 2021 MDPI].