TABLE II.

Comparison between microarrays and RNA-Seq. Adapted from Ref. 57.

Feature	Microarray	RNA-seq
Principle	Hybridization	Cloning and sequencing
Required amount of RNA	High	Low
Resolution	Several to ∼100 base pairs	Single base
Sensitivity	Low	High
Dynamic range	Low	High
Target analysis	Known transcripts only	Novel transcripts identified
Identify alternative splicing forms	Limited	Yes
Identify allelic expression	Limited	Yes
Reproducibility	Yes	Yes
Cost	Medium	High, due to sample preparation and sequencing