Figure 1. NRP1 structure and key amino acid residues of the extracellular domains mediating VEGF binding or undergoing post-translational modification.

Schematic illustrating NRP1 structure and organisation in seven domains (a1, a2, b1, b2, c, TM, Cyto). The schematic shows the interactions of NRP1 with VEGFA and highlights the amino acid residues contributing to VEGFA binding or subjected to glycosaminoglycan modification. Highlighted in red are the amino acids in the b1 domain essential for VEGF binding.