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. 2024 Feb 7;52(1):137–150. doi: 10.1042/BST20230329

Figure 3. NRP1 regulation of TGF-β signalling is cell-specific.

Figure 3.

(A) Schematic diagram showing the role of NRP1 in activating TGF-β signalling and downstream effectors in non-ECs to modulate cell invasion, cell migration and mitochondria homeostasis. (B) Diagram describing that NRP1 promotes sprouting angiogenesis by acting as an inhibitor of TGF-β signalling, which induces a stalk phenotype [39] characterised by decreased cell migration, therefore reducing sprouting angiogenesis.