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. 2024 Feb 7;52(1):137–150. doi: 10.1042/BST20230329

Figure 4. Schematic illustration of the working model intertwining NRP1, VE-cadherin and TGFBR2 to regulate TGF-β signalling.

Figure 4.

NRP1 interacts with VE-cadherin and p120 catenin (P120) leading to adherens junction stability and endothelial monolayer integrity in cells exposed to laminar flow shear stress for 24 h. By promoting adherens junction stability, NRP1 suppresses phosphorylation of SMAD2/3 downstream of TGF-β receptors, preventing endothelial activation. Under laminar flow, NRP1 prevents the transcription of pro-inflammatory genes, reducing the interaction between ECs and inflammatory cells and preventing atherosclerosis.