Skip to main content
. 2024 Feb 7;52(1):137–150. doi: 10.1042/BST20230329

Figure 5. NRP1 forms a mechanosensory complex with PLXD1 and VEGFR2.

Figure 5.

Short-term application of laminar flow shear stress (2–5 min) induces the assembly of a mechanosensory complex formed by NRP1, PLXD1 and VEGFR2. NRP1 is essential to promote the formation of the complex and PLXD1 acts as the mechanosensor, with flow shear stress inducing flexion and conformational changes of PLXD1 ectodomain (curved arrow). Activation of the mechanosensory complex induces phosphorylation of VEGFR2 and downstream signalling, promoting EC response to flow.