Table 3.
Association of strawberry and pelargonidin intake with AD pathology among deceased participants of the Rush Memory and Aging Project Stratified by their APOE ε4 status
| Stratified analysis | Global AD pathology burden | Amyloid-β Load | Phosphorylated tau tangles |
|---|---|---|---|
| Strawberry Intake (Model A) β (SE, p); | |||
| APOE ε4 non-carriers (n = 452) | −0.058 (0.03, 0.076) | −0.150 (0.11, 0.172) | −0.227 (0.11, 0.037) |
| APOE ε4 carriers (n = 120) | 0.019 (0.06, 0.761) | −0.139 (0.19, 0.476) | 0.292 (0.11, 0.292) |
| Pelargonidin Intake* (Model B) | |||
| APOE ε4 non-carriers (n = 452) | |||
| Quartile 1; n = 115 | Ref | Ref | Ref |
| Quartile 2 β (SE, p); n = 116 | 0.011 (0.05, 0.804) | −0.061 (0.16, 0.696) | −0.166 (0.15, 0.283) |
| Quartile 3 β (SE, p); n = 105 | −0.073 (0.05, 0.131) | −0.329 (0.16, 0.042) | −0.301 (0.16, 0.060) |
| Quartile 4 β (SE, p); n = 117 | −0.101 (0.05, 0.033) | −0.291 (0.16, 0.067) | −0.401 (0.16, 0.011) |
| p for trend | 0.013 | 0.043 | 0.010 |
| APOE ε4 carriers (n = 120) | |||
| Quartile 1; n = 28 | Ref | Ref | Ref |
| Quartile 2 β (SE, p); n = 28 | −0.039 (0.10, 0.69) | −0.087 (0.30, 0.770) | −0.225 (0.46, 0.626) |
| Quartile 3 β (SE, p); n = 39 | 0.038 (0.09, 0.69) | −0.082 (0.29, 0.774) | −0.136 (0.44, 0.757) |
| Quartile 4 β (SE, p); n = 25 | 0.047 (0.11, 0.66) | −0.243 (0.33, 0.460) | 0.315 (0.49, 0.525) |
| p for trend | 0.53 | 0.463 | 0.430 |
Linear regression models: Model A: adjusted for age at death, sex, education, and total calories.
*
Calorie-adjusted pelargonidin intake; Model B: adjusted for age at death, sex, education, vitamin E, and vitamin C.