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. 2024 Feb 29;19(2):e0298151. doi: 10.1371/journal.pone.0298151

Table 2. Comparison between the remission and non-remission groups of NAFLD from baseline to month 12.

Baseline Month 12 Difference between baseline and month 12 P
BMI, kg/m2
Remission group 29.29 ± 3.30 28.04 ± 3.30 −1.25 <0.001
Non-remission group 28.72 ± 3.30 28.50 ± 3.20 −0.22
WC, cm
Remission group 96.05 ± 7.99 92.13 ± 8.81 −3.92 <0.001
Non-remission group 93.86 ± 8.20 93.59 ± 8.41 −0.27
SBP, mmHg
Remission group 123.74 ± 11.05 121.41 ± 11.06 −2.33 0.539
Non-remission group 125.46 ± 13.62 121.59 ± 12.14 −3.87
DBP, mmHg
Remission group 76.82 ± 9.51 75.44 ± 9.90 −1.38 0.691
Non-remission group 79.03 ± 10.21 76.89 ± 8.76 −2.14
AST, IU/L
Remission group 34.76 ± 16.21 30.09 ± 17.08 −4.67 0.110
Non-remission group 31.99 ± 13.75 33.28 ± 21.83 1.29
ALT, IU/L
Remission group 41.88 ± 24.13 30.88 ± 26.91 −11 0.020
Non-remission group 38.84 ± 20.99 39.57 ± 30.77 0.73
r-GTP, IU/L
Remission group 83.68 ± 198.8 67.32 ± 160.25 −16.36 0.172
Non-remission group 52.78 ± 60.49 49.11 ± 46.73 −3.67
Albumin, g/dL
Remission group 4.45 ± 0.25 4.49 ± 0.21 0.04 0.037
Non-remission group 4.56 ± 0.24 4.49 ± 0.25 −0.07
TC, mg/dL
Remission group 197.50 ± 36.55 188.85 ± 43.73 −8.65 0.995
Non-remission group 199.88 ± 42.32 191.28 ± 38.74 −8.6
TG, mg/dL
Remission group 219.44 ± 211.67 156.53 ± 88.29 −62.91 0.198
Non-remission group 190.62 ± 207.98 176.93 ± 109.76 −13.69
HDL-C, mg/dL
Remission group 46.56 ± 12.80 51.29 ± 16.14 4.73 0.001
Non-remission group 48.04 ± 10.82 48.08 ± 11.00 0.04
FBS, mg/dL
Remission group 117.09 ± 46.73 111.5 ± 30.25 −5.59 0.524
Non-remission group 112.89 ± 28.06 110.53 ± 22.07 −2.36
HbA1c, %
Remission group 6.30 ± 1.17 6.10 ± 0.91 −0.2 0.434
Non-remission group 6.15 ± 1.19 6.05 ± 0.78 −0.1
Insulin, mIU/L
Remission group 13.74 ± 7.07 10.94 ± 5.84 −2.8 0.035
Non-remission group 12.48 ± 6.61 12.32 ± 7.56 −0.16
FF, %†
Remission group 17.51 ± 9.34 6.39 ± 3.87 −11.12 <0.001
Non-remission group 17.25 ± 7.91 16.71 ± 8.34 −0.54
M2BPGi, COI
Remission group 0.73 ± 0.22 0.67 ± 0.25 −0.06 0.330
Non-remission group 0.68 ± 0.30 0.67 ± 0.27 −0.01
Liver fibrosis based on MRE
Remission group 2.08 ± 0.68 2.06 ± 0.68 −0.02 0.178
Non-remission group 2.15 ± 0.58 2.30 ± 0.52 0.15  

Data are mean±standard-deviation values

Abbreviation: NAFLD, non-alcoholic fatty liver disease; BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; AST, aminotransferase; ALT, alanine aminotransferase; r-GTP, gamma-glutamyl transpeptidase; TC, total cholesterol; TG, triglyceride; HDL-C, HDL-cholesterol; FBS, fasting blood sugar; HbA1c, hemoglobin A1C; FF, fat fraction; M2BPGi, Mac-2 binding protein glycosylation isomer; COI, cutoff index; MRE, magnetic resonance elastography.