Table 2.

Characteristics of FDA-approved DTxs in the field of mental health

reSET	Somryst	EndeavorRx
• Cognitive behavioural therapy • 12 weeks (90 days) prescription-only treatment • Patients with substance use disorder from 18 years old • Aims: increase abstinence during treatment and increase retention in the outpatient treatment program • Lessons: identifying situations and triggers that make substance use more likely, avoiding substance use, coping with thoughts about substance use, recognizing negative thinking and identifying techniques to move to positive thinking, making decisions about substance use, taking responsibility for choices made and evaluating the consequences of those choices. • Every lesson is delivered primarily through text, sometimes videos, animations and graphics. • After most therapy lessons, patients undergo a questionnaire to evaluate learning.	• Cognitive behavioural therapy • 9 weeks (63 days) prescription-only treatment • Patients with chronic insomnia from 22 years old • Aims: improving patients’ insomnia symptoms • The therapy consists in text, video, animation and graphics.	• 25 min per day for 5 days per week • Patient with Attention Deficit Hyperactivity Disorder (ADHD) from 8–12 years old • EndeavorRx has to be considered for use as part of a therapeutic program • EndeavorRx is built on Akili's proprietary, patented, technology platform and uses adaptive algorithms (also known as Selective Stimulus Management Engine, SSME) to deliver stimuli that are designed to engage the patient in a manner that improves their attention function. In a closed-loop system, the adaptive SSME algorithms automatically adjust the difficulty level for a personalized treatment experience that is tailored to the needs of each individual patient. • Delivered through a video game experience which leverages art, music, storytelling, and reward cycles to keep patients engaged. • The basic program inputs are steering, which is accomplished by using the internal accelerometer to measure the degree to which the mobile device is tilted, and tapping, which is accomplished using the touch screen to measure correct and incorrect targeting. The basic outputs are a visual display of the game progression along with audio, which is accomplished by using the internal high-resolution display and internal speaker.

CBT, cognitive behaviour therapy; DTx, digital therapeutics.