Table 2.
Baseline demographics of the selected trials
| Case/Control, % | STOPDAPT-2 ACS | MASTER DAPTa | TICO | TWILIGHT-ACS | GLOBAL LEADERSa | SMART- CHOICEa | REDUCE | OPTIMIZEa | RESETa |
|---|---|---|---|---|---|---|---|---|---|
| Age, year | 67.0/66.6 | 76.1/76.0 | 61.0/61.0 | 64.2/64.2 | 64.9/64.8 | 64.6/64.4 | 61.0/60.0 | 61.3/61.9 | 62.4/62.4 |
| Female | 20.8/20.6 | 30.7/30.8 | 21.0/20.0 | 25.5/24.8 | 23.2/22.9 | 27.3/25.8 | 17.4/22.7 | 36.5/36.9 | 35.6/37.1 |
| BMI, mean | 24.1/24.2 | 27.3/27.4 | 24.9/24.9 | 28.4/28.4 | – | 24..5/24.7 | 26.6/26.6 | – | 25.0/24.9 |
| Diabetes mellitus | 29.5/29.9 | 32.9/34.3 | 27.0/27.0 | 35.6/34.3 | 21.6/21.2 | 38.2/36.8 | 21.6/19.5 | 35.4/35.3 | 29.8/28.8 |
| Hypertension | 67.8/68.1 | 76.9/78.2 | 50.0/51.0 | 67.5/67.4 | 68.6/67.9 | 61.6/61.3 | 50.7/50.7 | 86.4/88.2 | 62.3/61.4 |
| Dyslipidemia | 66.7/66.9 | 67.2/68.1 | 61.0/60.0 | – | 60.8/62.0 | 45.1/45.5 | 46.3/44.9 | 63.2/63.7 | 57.7/59.9 |
| Current smoking | 34.9/33.8 | 10.0/8.1 | – | 23.3/26.6 | 34.3/33.6 | 28.4/24.5 | 42.1/42.7 | 18.6/17.3 | 25.2/22.8 |
| Impaired renal fx | 3.3/3.4 | 18.2/20.1 | 19.0/22.0 | 14.6/15.1 | 13.4/12.5 | 2.9/3.5 | – | 7.4/5.8 | – |
| PAD | 1.9/2.0 | – | – | 5.7/5.6 | 5.1/5.3 | – | – | 2.8/3.0 | – |
| Previous MI | 6.6/5.3 | 18.9/18.8 | 4.0/3.0 | 25.4/25.2 | 18.3/18.6 | 4.1/4.3 | – | 34.6/34.8 | 1.8/1.6 |
| Previous ACS | – | – | – | – | – | – | 12.5/11.8 | 31.6/32.3 | – |
| Previous PCI | 10.9/9.7 | 25.9/26.0 | – | 34.2/34.4 | 22.8/23.4 | 11.5/11.8 | 11.7/9.8 | 20.9/19.1 | 3.5/3.0 |
| Previous CABG | 0.4/0.9 | 7.4/7.5 | 1.0/1.0 | 8.8/8.5 | 3.5/3.9 | – | 2.8/2.8 | 7.1/8.2 | 0.2/0.6 |
| Previous CVA | 4.8/4.6 | – | 4.0/4.0 | – | 2.2/2.5 | 6.6/6.8 | 1.5/2.0 | 2.5/2.5 | – |
| Previous bleeding | 0.9/0.7 | 7.2/6.8 | – | 0.9/0.7 | 0.6/0.6 | – | – | 0.6/0.6 | – |
| LVEF, mean | 56.7/56.9 | 53.5/53.0 | – | – | – | 60.0/59.9 | – | – | 64.2/63.9 |
| MVD | – | – | 55.0/56.0 | 61.9/59.5 | – | 50.1/49.0 | 36.1/33.8 | – | 43.1/42.9 |
| Unstable angina b | 23.3/24.4 | 23.0/24.1 | 29.0/32.0 | 54.9/53.1 | 26.8/27.2 | 53.6/56.4 | 15.2/13.8 | 82.9/83.3 | 73.5/74.3 |
| NSTEMI b | 2.0/2.8 | 52.7/51.5 | 35.0/32.0 | 45.1/46.9 | 44.9/45.2 | 27.5/26.5 | 35.6/41.0 | 17.1/16.7 | 26.5/25.7 |
| STEMI b | 74.7/72.8 | 24.2/24.5 | 36.0/36.0 | – | 28.3/27.6 | 18.9/17.2 | 49.3/45.2 | – |
a
Demographics and comorbidities of the entire sample, including all silent ischemia, stable angina, and acute coronary syndrome
b
Clinical presentation
c
Includes both unstable angina and STEMI
Abbreviations: ACS = acute coronary syndrome; BMI = body mass index; CABG = coronary artery bypass graft; CAD = coronary artery disease; CVA = cerebrovascular disease; fx = function; LVEF = left ventricular ejection fraction; MI = myocardial infarction; MVD = multivessel disease; NSTEMI = non-ST segment elevation myocardial infarction; PAD = peripheral vascular disease; PCI = percutaneous coronary intervention; STEMI = ST segment elevation myocardial infarction