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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Nat Genet. 2023 Aug 14;55(9):1503–1511. doi: 10.1038/s41588-023-01474-z

Figure 3. TCSC estimates tissue-specific contributions to disease and complex trait heritability.

Figure 3.

We report estimates of the proportion of disease heritability explained by the cis-genetic component of gene expression in tissue t(πt). We report tissue-trait pairs with FDR of 10% or lower, where full boxes denote FDR of 5% or lower and partial boxes denote FDR between 5% and 10%. Dashed boxes denote results that are highlighted in the main text. Tissues are ordered alphabetically. Daggers denote meta-tissues with more than one constituent tissue. Diseases/traits are ordered with respect to causal tissues. Numerical results are reported in Supplementary Tables 56. WHRadjBMI: waist-hip-ratio adjusted for body mass index. HDL: high-density lipoprotein. DBP: diastolic blood pressure. BMI: body mass index. FEV1/FVC: forced expiratory volume in one second divided by forced vital capacity. Cereb. Cortex Ar.: cerebral cortex surface area. AST: aspartate aminotransferase. LDL: low-density lipoprotein. WBC Count: white blood cell count. MDD: major depressive disorder.