Table 4.
Prevalence of AIDs in control individuals and individuals with type 1 diabetes at end of follow-up
| AID | Control individuals | Individuals with T1D | HR (95% CI) | ||||
|---|---|---|---|---|---|---|---|
| Overall | Female individuals | Male individuals | Overall | Female individuals | Male individuals | ||
| n | 74,210 | 33,085 | 41,125 | 15,188 | 6774 | 8414 | |
| One AID | 2765 (3.7) | 1524 (4.6) | 1241 (3.0) | 2562 (16.9)*** | 1436 (21.2) | 1126 (13.4) | – |
| Two AIDs | 204 (0.3) | 121 (0.4) | 83 (0.2) | 311 (2.0)*** | 192 (2.8) | 119 (1.4) | – |
| Three or more AIDs | 27 (0.0) | 17 (0.1) | 10 (0.0) | 43 (0.3)*** | 24 (0.4) | 19 (0.2) | – |
| Coeliac disease | 712 (1.0) | 429 (1.3) | 283 (0.7) | 1604 (10.6) | 864 (12.8) | 740 (8.8) | 11.55 (10.58, 12.62) |
| Thyroid disease | 518 (0.7) | 377 (1.1) | 141 (0.3) | 1072 (7.1) | 717 (10.6) | 355 (4.2) | 10.61 (9.56, 11.79) |
| Psoriasis | 498 (0.7) | 225 (0.7) | 273 (0.7) | 130 (0.9) | 68 (1.0) | 62 (0.7) | 1.28 (1.06, 1.55) |
| Vitiligo | 134 (0.2) | 70 (0.2) | 64 (0.2) | 112 (0.7) | 46 (0.7) | 66 (0.8) | 4.09 (3.19, 5.26) |
| Rheumatic joint disease | 309 (0.4) | 176 (0.5) | 133 (0.3) | 109 (0.7) | 72 (1.1) | 37 (0.4) | 1.73 (1.39, 2.15) |
| Inflammatory bowel disease | 431 (0.6) | 194 (0.6) | 237 (0.6) | 88 (0.6) | 30 (0.4) | 58 (0.7) | 1.00 (0.80, 1.26) |
| SCTD | 385 (0.5) | 220 (0.7) | 165 (0.4) | 75 (0.5) | 42 (0.6) | 33 (0.4) | 0.95 (0.74, 1.22) |
| Uveitis | 222 (0.3) | 98 (0.3) | 124 (0.3) | 65 (0.4) | 30 (0.4) | 35 (0.4) | 1.44 (1.09, 1.90) |
| Addison’s disease | 8 (0.0) | 5 (0.0) | 3 (0.0) | 30 (0.2) | 8 (0.1) | 22 (0.3) | 18.33 (8.40, 39.98) |
| Multiple sclerosis | 28 (0.0) | 20 (0.1) | 8 (0.0) | 10 (0.1) | 6 (0.1) | 4 (0.0) | 1.76 (0.86, 3.63) |
| Inflammatory liver disease | 12 (0.0) | 5 (0.0) | 7 (0.0) | 9 (0.1) | 3 (0.0) | 6 (0.1) | 3.68 (1.55, 8.73) |
| Atrophic gastritis | 2 (0.0) | 1 (0.0) | 1 (0.0) | 8 (0.1) | 6 (0.1) | 2 (0.0) | 19.61 (4.16, 92.34) |
| Total number of autoimmune diagnoses | 3259 | 1820 | 1440 | 3312 | 1938 | 1419 | – |
Data are shown as n (%) or n
***p<0.01 vs overall control population
SCTD, systemic connective tissue disorder; T1D, type 1 diabetes