Table 2.

SPRINT estimates of number-needed-to-harm based on reported SAEs^a

Rx Group	All (9361) / Events	≥ 80 years (1167) / Events	≥ 80 years (MoCA+ [754]b	< 80 years (8194)
Intensive	15.1% (707/ 4678)	34.1% (200/ 586)	32.3% (122/ 378)	12.4% (507/ 4092)
Standard	11.1% (519/ 4683)	28.6% (166/ 581)	26.9% (101/ 376)	8.6% (353/ 4102)
NNH	25	18	19	27

^aSAEs included hypotension, syncope, bradycardia, electrolyte abnormality, injurious fall, or AKI or ARF) over the course of the trial. Estimated cumulative incidence of SAEs over the Intervention Period, comprised of hypotension, syncope, bradycardia, electrolyte abnormality, injurious fall, and AKI or ARF. Study participants may be counted in more than one SAE

^bMoCA+ , Montreal Cognitive Assessment scores > 18 for participants with less than high school (HS) education and > 20 for ≥ HS