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. 2024 Feb 16;15:1297508. doi: 10.3389/fimmu.2024.1297508

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Copyright © 2024 Guo, He and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hematoxylin-eosin staining of the intestinal mucosal. (A) Hematoxylin-eosin staining of the colonic mucosa before colectomy. Colon pathology showed mucosal erosion, ulcers, cryptitis and granulation tissue hyperplasia. (B) Hematoxylin-eosin staining of the intestinal mucosa after colectomy. Ileum pathology showed villus atrophy and shortening, mucosal erosion, cryptitis with irregular crypt structure and infiltrated lymphocytes and plasma cells. (C) Hematoxylin-eosin staining of the intestinal mucosa after after 1 year of ustekinumab treatment. Ileum pathology showed a reduction in lymphocytes and plasma cells compared to before, with regular crypt structures.