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. 2023 Sep 26;47(3):739–747. doi: 10.1007/s40618-023-02199-w

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Fig. 1 — Diagnostic flowchart for children with suspected HPP. The main pathway includes the assessment of circulating ALP activity, followed by the measurement of serum vitamin B6 concentration (solid line). Whenever the latter is not feasible, the diagnosis may be confirmed performing molecular analysis directly (dotted line)