Table 2.

Main causes of hypophosphatasaemia

Clofibrate therapy	Folic acid deficiency
Bisphosphonate therapy	Zn2+ deficiency
Denosumab therapy	Mg2+ deficiency
Corticosteroid therapy	Cleidocranial dysplasia
Estrogen therapy	Type II osteogenesis imperfecta
Vitamin D toxicity	Wilson's disease
Radioactive heavy metals toxicity	Cushing's syndrome
Cardiac surgery with bypass	Hypothyroidism
Celiac disease	Hypoparathyroidism
Pernicious or severe anemia	Massive transfusions
Malnutrition	Milk-alkali syndrome
Vitamin C deficiency	Multiple myeloma
Vitamin B12 deficiency