Table 3.

Specific Red Flags according to the severity of HPP

Severe form	Moderate form	Mild form
Early seizures occurring in the first few days of life (tonic/spasms/myoclonic), typically resistant to antiseizure medications	Seizures, predominantly focal, non-responsive to antiseizure medications	Headache
Hypotonic syndrome	Headache	Sleep disturbances
Psychomotor delay	Sleep disturbances	Anxiety-depressive syndrome
Irritability	Anxiety-depressive syndrome	Cognitive disturbances (memory and attention deficit)
	Neuropathy
	Vestibular-cochlear symptoms
	Syncope
	Cognitive disturbances (memory and attention deficit)