TABLE 6.
Information on synthesized pyrano[2,3-c]pyrazole derivatives using choline chloride/urea as green method.
| Product code | R1 | R2 | Product structure | Reported Mp (°C) | Found Mp (°C) | Synthesis time (min) | Yield (%) |
|---|---|---|---|---|---|---|---|
| 6a | Ph | H |
|
241-243 (Yekke-Ghasemi et al., 2022) | 240-242 | 17 | 95 |
| 6b | Ph | Ph |
|
169-171 (Mathavan and Yamajala, 2023) | 170-172 | 15 | 95 |
| 6c | Ph | 2,4-NO2-Ph |
|
240-243 (Vasava et al., 2019) | 241-242 | 30 | 90 |
| 6d | 4-Me-Ph | H |
|
175-177 (El Mejdoubi et al., 2019) | 176-178 | 25 | 90 |
| 6e | 4-Me-Ph | Ph |
|
177-179 (Mohamadpour, 2020) | 177-180 | 25 | 95 |
| 6f | 4-Me-Ph | 2,4-NO2-Ph |
|
New | 270-273 | 35 | 85 |
| 6g | 4-OMe-Ph | H |
|
209-211 (Yekke-Ghasemi et al., 2022) | 209-212 | 20 | 92 |
| 6 h | 4-OMe-Ph | Ph |
|
170 (Suryakumari and Sudhakar, 2023) | 169-171 | 18 | 95 |
| 6i | 4-OMe-Ph | 2,4-NO2-Ph |
|
New | 288-290 | 36 | 85 |
| 6j | 4-NO2-Ph | H |
|
249-251 (Moghaddam et al., 2023) | 249-251 | 20 | 95 |
| 6k | 4-NO2-Ph | Ph |
|
195-197 (Kondabanthini et al., 2022) | 194-196 | 19 | 95 |
| 6L | 4-NO2-Ph | 2,4-NO2-Ph |
|
283-285 (Vasava et al., 2019) | 284-285 | 34 | 88 |
| 6m | 4-Cl-Ph | H |
|
234-236 (Yekke-Ghasemi et al., 2022) | 235-236 | 20 | 94 |
| 6n | 4-Cl-Ph | Ph |
|
175-177 (Kondabanthini et al., 2022) | 175-177 | 17 | 97 |
| 6o | 4-Cl-Ph | 2,4-NO2-Ph |
|
260-265 (Vasava et al., 2019) | 263-266 | 35 | 80 |
Choline Chloride: Urea (1: 2); 70°C