TABLE 8.

Antibacterial activity of pyrazole derivatives (4a-j) and pyrazole pyrano[2,3-c]pyrazole derivatives (6a-o) against Gram-positive strains.

Strains		Pyrazole derivatives										Drugs		Pyrano[2,3-c]pyrazole derivatives
		4a	4b	4c	4d	4e	4f	4g	4h	4i	4j	A	B	6a	6b	6c	6d	6e	6f	6g	6h	6i	6j	6k	6l	6m	6n	6o
10745	(I)	2048	128	-	256	1024	128	512	128	64	64	-	16	512	512	128	1024	256	64	256	128	32	64	64	32	16	16	8
	(II)	4096	256	-	512	2048	128	1024	128	128	128	-	32	1024	512	128	1024	512	128	256	256	64	64	64	64	16	32	16
	(III)	12.6	16.8	-	16.2	12.8	17.3	13.7	15.9	18.2	17.3	-	17.3	14.5	14.9	14.3	15.3	14.8	18.9	17.6	18.5	19.1	18.2	21.2	20.3	22.5	19.9	22.4
29213	(I)	-	-	-	-	-	-	-	-	-	-	16	16	-	-	2048	-	-	512	-	-	256	1024	1024	128	-	-	64
	(II)	-	-	-	-	-	-	-	-	-	-	32	16	-	-	4096	-	-	1024	-	-	512	2048	1024	256	-	-	128
	(III)	-	-	-	-	-	-	-	-	-	-	15.1	16.9	-	-	12.2	-	-	13.8	-	-	13.6	12.3	12.9	14.2	-	-	14.1
19615	(I)	4096	4096	2048	1024	2048	2048	2048	2048	1024	1024	2	8	512	512	16	512	512	8	256	128	4	64	32	4	2	2	2
	(II)	4096	4096	2048	4096	2048	2048	4096	2048	2048	2048	4	16	1024	1024	16	1024	1024	16	512	128	8	128	64	4	4	2	2
	(III)	10.4	10.9	10.7	10.2	10.5	11.3	10.4	10.6	11.8	11.5	23.2	18.4	16.4	18.3	20.8	15.9	19.9	19.7	18.8	19.5	23.1	19.4	21.6	22.5	23.1	22.7	22.9
12386	(I)	-	-	-	-	-	-	-	-	1024	1024	-	4	-	-	64	-	-	32	256	128	16	128	128	8	8	4	2
	(II)	-	-	-	-	-	-	-	-	4096	2048	-	8	-	-	128	-	-	64	512	256	16	128	128	16	8	8	4
	(III)	-	-	-	-	-	-	-	-	18.2	17.5	-	19.1	-	-	21.6	-	-	21.0	17.3	16.6	22.1	16.2	19.4	22.4	21.5	21.7	22.3

(I): Minimum Inhibitory Concentration (μg/mL); (II): Minimum Bactericidal Concentration (μg/mL); (III): Inhibition Zone Diameter (mm);

A, penicillin; B, cefazolin.