TABLE 2.

Clinical applications of alloferon.

Disease	Therapy	Mode of action and biological effect	References
Pancreatic cancer (PCa)	Combined therapy with gemcitabine	As an adjuvant, increased the chemosensitivity of cells to chemotherapy drug, apoptosis of infected cells	Min et al. (2002)
Locally advanced cervical cancer (LACC)	Combined therapy with neoadjuvant polychemotherapy (NAPCT)	Rapid tumor elimination, prevents relapses	Menshenina et al. (2021)
Leukemia	Immunochemotherapy of alloferon and chemotherapy	Improved antitumor activity over conventional cytostatic chemotherapy, release IFN-γ and TNF-α, prevents autoimmunity	Chernysh et al. (2012)
Chronic endometritis	Combined therapy with valacyclovir	Eliminates HPV, lessens severity of chronic endometritis	Tapilskaya et al. (2022)
Chronic Epstein-Barr Virus Infection (CEBVI)	Allokin-alpha	Reduces DNA EBV, improves recognition of virus-infected cells, suppresses viral replication	Rakitianskaya et al. (2019a)
Chronic fatigue syndrome	Allokin-alpha	Decreases HHV-6 and EBV DNA, produces interferon	Rakitianskaya et al. (2019b)
Genitourinary infections	Combination of conventional enzyme therapy with allokin-alpha	Rapid and complete eradication of STI pathogens	Akimov et al. (2013)
Metabolic syndrome	Alloferon monotherapy, combined therapy with pyrogenal and cytokine	Positive changes in lipid profile, reduced systemic inflammation	Didkovsky et al. (2019)