Table 2.
Summary of articles describing the cutaneous microbiota in patients with cutaneous T-cell lymphoma (CTCL). The table shows the main findings and methods of each study.
| Study | Type of sample | Method of analysis | Summary | Key finding |
|---|---|---|---|---|
| 17. Zhang et al. (2021) | Skin swabs from mycosis fungoides patients | 16S rRNA gene sequencing | Analysis of bacterial diversity in lesional and nonlesional skin and relation to CTCL symptoms | Alterations in the skin microbiota are associated with symptom and phenotype in mycosis fungoides |
| 16. Dehner et al. (2018) | Skin samples from cutaneous T-cell lymphoma patients | 16S rRNA gene sequencing | Investigates the role of skin microbiota as antigenic triggers for cutaneous T-cell lymphoma | Presence of Bacillus safensis only in CTCL patients |
| 14. Salava et al. (2020) | Skin swabs from cutaneous T-cell lymphoma patients | 16S rRNA and whole-genome sequencing | Explores the skin microbiome in cutaneous T-cell lymphoma using 16S rRNA and whole-genome shotgun sequencing | Cutaneous T-cell lymphoma patients have distinct skin microbiome profiles compared to healthy controls. 10 bacterial species more abundant in nonlesional skin∗ |
| 15. Harkins et al. (2021) | Skin samples from cutaneous T-cell lymphoma patients | Shotgun metagenomic sequency | Examines the cutaneous T-cell lymphoma skin microbiome and its shifts in certain commensal bacteria. | Higher abundance of Corynebacterium spp. and lower abundance of Cutibacterium spp. In CTCL patients |
| 19. Hooper et al. (2022) | Cutaneous microbial changes in CTCL patients treated with UV | 16S gene sequencing | Examination of microbial changes in the skin of CTCL patients treated with UV, noting differences in microbial richness and in microbial communities in response to | Differences in UV treatment response between responders and nonresponders, with specific changes in the abundance of certain bacteria. |
∗ Streptomyces sp. SM17, Bordetella pertussis, Streptomyces sp. PVA 94-07, Methylobacterium oryzae, Serratia sp. LS-1, Burkholderia mallei, Enterobacteriaceae bacterium, Achromobacter ruhlandii, Pseudomonas sp. A214, and Pseudomonas sp. st29.