Table 3.
Assessment of the gene expression levels of cGAS and STING and plasma levels of the cytokines IFN-α, TNF-α and IL-6 according to established risk factors for the severity of acute COVID-19.
| Variables | cGAS (RQ) | STING (RQ) | IFN-α (pg/mL) | TNF-α (pg/mL) | IL-6 (pg/mL) |
|---|---|---|---|---|---|
| Median (IIQ) | Median (IIQ) | Median (IIQ) | Median (IIQ) | Median (IIQ) | |
| Sex | |||||
| Male | 0.26 (0.96) | 0.33 (1.12) | 7.6 (9.3) | 6.10 (3.84) | 12.96 (7.33) |
| Female | 0.46 (0.86) | 0.28 (1.25) | 2.6 (14.5) | 6.75 (3.88) | 11.55 (5.23) |
| p | 0.6461 | 0.7777 | 0.4507 | 0.7553 | 0.481 |
| Age | |||||
| 21–40 | 0.14 (0.46) | 0.11 (0.58) | 1.2 (9.3) | 7.44 (4.56) | 11.39 (5.65) |
| 41–60 | 0.57 (2.6) | 0.56 (1.21) | 14.2 (30.8) | 6.54 (4.11) | 13.01 (17.23) |
| > 60 | 0.29 (0.71) | 0.17 (0.69) | 1.9 (13.8) | 5.72 (3.54) | 12.93 (7.29) |
| p | 0.1964 | 0.0095 | 0.0224 | 0.6396 | 0.2873 |
| Comorbidities | |||||
| Present | 0.37 (1.22) | 0.31 (1.02) | 10.7 (24.2) | 5.86 (3.27) | 13.03 (11.32) |
| Absent | 0.27 (0.72) | 0.29(1.20) | 3.4 (17.1) | 7.05 (4.45) | 11.53 (5.28) |
| p | 0.2666 | 0.7268 | 0.2939 | 0.0827 | 0.1658 |
IIQ: interquartile range. Comorbidities: diabetes mellitus, chronic cardiovascular disease, obesity, chronic kidney disease.