Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 29;14:4967. doi: 10.1038/s41598-024-55315-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effect of local delivery of 7 nM AaH-II on the Na⁺ and Ca²⁺ influx associated with the AP in the AIS. (A) Top, fluorescence image (Na⁺ indicator ING-2) of the AIS and its reconstruction with a region of interest indicated. Middle, somatic AP in control solution (black trace) and after delivering 7 nM of AaH-II (grey trace). Bottom, associated Na⁺ transients fitted with a model function to calculate the Na⁺ current (I_Na) in control solution (green trace) and after delivering 7 nM of AaH-II (grey trace). (B) Top, fluorescence image (Ca²⁺ indicator OG5N) of the AIS and its reconstruction with a region of interest indicated. Middle, somatic AP in control solution (black trace) and after delivering 7 nM of AaH-II (grey trace). Bottom, associated Ca²⁺ transients fitted with a model function to calculate the Ca²⁺ current (I_Ca) in control solution (blue trace) and after delivering 7 nM of AaH-II (grey trace). (C) Mean ± SD (N = 9 cells) of the Na⁺ (green lines and symbols) and Ca²⁺ (blue lines and symbols) changes following AaH-II addition. Values reported in the plot were 85.2 ± 25.9%for Na⁺ and 11.1 ± 5.3% Ca²⁺. “*” indicates that the change was significant for the Na⁺ (p = 1.07·10^–6, paired t-test) and for Ca²⁺ (p = 1.58·10^–5, paired t-test).