Table 1.
Mean ± SEM of the % change of the amplitude (N of cells) of the Nav1.2 and Nav1.6 current produced by AaH-II at different concentrations in HEK293 cells expressing either one or the other VGNC.
| 0.01 nM | 0.03 nM | 0.1 nM | 0.3 nM | 1 nM | 3.3 nM | 10 nM | |
|---|---|---|---|---|---|---|---|
| Nav1.2 | 8.2 ± 9.7 (N = 7) | 14.4 ± 3.2 (N = 6) | 6.9 ± 11.7 (N = 4) | 30.2 ± 5.7 (N = 5) | 31.8 ± 9.9 (N = 9) | 30.4 ± 9.4 (N = 4) | 56.5 ± 11.4 (N = 6) |
| Nav1.6 | 8.3 ± 2.4 (N = 7) | -1.8 ± 4.2 (N = 9) | -0.0 ± 3.3 (N = 2) | 4.5 ± 3.4 (N = 20) | 9.8 ± 3.3 (N = 16) | 20.7 ± 6.7 (N = 20) | 13.6 ± 5.0 (N = 17) |