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. 2024 Feb 9;27(3):109166. doi: 10.1016/j.isci.2024.109166

Figure 6.

Figure 6

TDP-43 MNs exhibit pre- and postsynaptic abnormalities

(A) Representative images of 6 weeks post-plating MN neurites subjected to immunocytochemistry for synapsin I and PSD95. Scale bar, 10 μm.

(B–D) Quantification of the average number (B), size (C), and intensity (D) of synapsin I+ puncta.

(E–G) Quantification of the average number (E), size (F), and intensity (G) of PSD95+ puncta.

(H and I) Quantification of the average number (H), and size (I) of synapsin I+/PSD95+ puncta. Individual points represent per-frame values from 3 independent experiments. All data shown as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. Ordinary one-way ANOVA.