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. 2024 Feb 5;12:394. Originally published 2023 Apr 13. [Version 4] doi: 10.12688/f1000research.132214.4

Table 3. The effect of vitamin D deficiency among each subgroup.

Variables Categories N (%) Serum 25(OH) D Level
Mean ± SD or median [IQR], in ng/mL p-value
Age groups ≤60 years old 125 (85.62%) 11.94 [7.69] 0.186 a
>60 years old 21 (14.38%) 9.74 ± 5.15
ISARIC-4C score Low risk 77 (52.74%) 12.07 ± 4.55 0.067 b
Intermediate risk 30 (20.55%) 10.75 ± 4.73
High risk 27 (18.49%) 9.22 ± 5.09
Very high risk 12 (8.22%) 10.97 ± 6.15
Number of comorbidities 0 46 (31.51%) 12.30 [8.06] 0.133 c
1 33 (22.60%) 10.90 ± 4.60
2 67 (45.89%) 10.52 ± 5.12
Type of comorbidities
DM type II No 93 (63.7%) 11.05 ± 4.79 0.675 d
Yes 53 (36.30%) 11.41 ± 5.12
Hypertension No 96 (65.75%) 11.21 ± 4.84 0.914 d
Yes 50 (34.25%) 11.12 ± 5.05
Cardiovascular disease No 133 (91.1%) 11.44 ± 4.85 0.040 d
Yes 13 (8.90%) 8.52 ± 4.72
Chronic kidney disease No 128 (87.7%) 11.49 ± 4.72 0.051 a
Yes 18 (12.3%) 7.75 [9.56]
Malignancy No 128 (87.67%) 11.37 ± 4.93 0.211 d
Yes 18 (12.33%) 9.83 ± 4.56
BMI Underweight 84 (57.53%) 11.73 [8.09] 0.082 c
Normoweight 6 (4.11%) 7.97 ± 3.54
Overweight 25 (17.12%) 12.47 ± 4.90
Obesity grade I 31 (21.23%) 9.93 ± 4.94
Mortality rate No 132 (90.41%) 11.58 ± 4.80 0.002 d
Yes 14 (9.59%) 7.44 ± 4.26
COVID-19 severity Mild 62 (42.47%) 11.78 ± 4.62 0.047 c
Moderate 55 (37.67%) 12.04 [6.64]
Severe 29 (19.86%) 7.37 [8.84]
HFNC or ventilator use No 126 (86.30%) 11.66 ± 4.70 0.004 a
Yes 20 (13.70%) 6.39 [7.99]

Abbreviations: BMI, body mass index; DM type II, diabetes mellitus type II; HFNC, High-flow nasal canule.

Bold value denotes statistical significance.

a

Analyzed using Mann-Whitney U test.

b

Analyzed using ANOVA test.

c

Analyzed using Kruskal-Wallis test.

d

Analyzed using t-test.