Table 5.
Overview of different nuclear receptors implicated in drug resistance in OC, covering specific drug, differential expression patterns, and their associated mechanisms
| Family of NRs |
Class
of NRs |
Gene name | Common name | Differential expression profile | Chemotherapy agent | Target-gene | Associated-mechanism | Ref. |
| 1C | II | PPARG | PPAR γ | Down | Cisplatin; paclitaxel | - | Apoptosis inhibition | [150] |
| 1H | II | NR1H3/NR1H2 | LXR α/LXR β | Up | Cisplatin; paclitaxel | MDR1 | Drug efflux | [151] |
| 1I | II | NR1I2 | PXR | Up | Cisplatin; paclitaxel | MDR1 | Drug efflux | [152] |
| 1I | II | NR1I3 | CAR | Up | Cisplatin; paclitaxel | MDR1 | Drug efflux | [153] |
| 2F | III | NR2F6 | COUP-TF γ | Up | Cisplatin | Notch3 | OCSCs | [154] |
| 3A | I | ESR1 | ER α | Up | Cisplatin | Bcl-2 | Apoptosis inhibition | [155] |
| 3A | I | ESR2 | ER β | Up | - | SOX2, OCT4 | OCSCs | [156] |
| 3B | IV | ESRRA | ERR α | Up | - | - | OCSCs | [157] |
| 3C | I | AR | AR | Up | Paclitaxel | ABCB1, ABCB6, ABCG2; AR/Ahr-ABCG2; TLR/IL-6/IRF1; NANOG | Drug efflux; OCSCs | [158-164] |
| 4A | IV | NR4A1 | NGF1-B | Down | Cisplatin | Bcl-2 | Apoptosis inhibition | [165] |
| 4A | IV | NR4A3 | NOR1 | Up | Cisplatin | - | - | [166] |
OC: Ovarian cancer; NR: nuclear receptor; PPARG: peroxisome proliferator-activated receptor gamma; PPAR: peroxisome proliferator activated receptor; NR1H3: nuclear receptor subfamily 1 group H member 3; NR1H2: nuclear receptor subfamily 1 group H member 2; LXR: liver X receptor; NR1I2: nuclear receptor subfamily 1 group I member 2; PXR: pregnane X receptor; CAR: constitutive androstane receptor; NR2F6: nuclear receptor subfamily 2 group F member 6; COUP-TF: chicken ovalbumin upstream promoter-transcription factor; Notch3: neurogenic locus notch homolog protein 3; OCSCs: ovarian cancer stem cells; ESR1: estrogen receptor 1; ER: estrogen receptor; SOX2: SRY-box transcription factor 2; AR: androgen receptor; ABCB6: ATP-binding cassette subfamily B member 6; ABCG2: ATP-binding cassette subfamily G member 2; NR4A1: nuclear receptor subfamily 4 group A member 1; NGF1-B: nerve growth factor 1B; NR4A3: nuclear receptor subfamily 4 group A member 3; NOR1: neuron-derived orphan receptor 1.