Table 1.
Details of the 25 candidate targets of Perillae Folium treating hyperuricemia.
| Target ID | UniProt ID | Target name | Target type | Total binding score (kcal/mol) | Average binding affinity (kcal/mol) |
|---|---|---|---|---|---|
| ZH01 | P47989 | XDH | Intersected/Drug target | -2216.7 | -6.76 |
| ZH02 | P08254 | MMP3 | Intersected target | -2151.6 | -6.56 |
| ZH03 | P21397 | MAOA | Intersected target | -2128.7 | -6.49 |
| ZH04 | P05091 | ALDH2 | Intersected target | -1975.6 | -6.02 |
| ZH05 | P45983 | MAPK8 | Intersected target | -2037.3 | -6.21 |
| ZH06 | Q14790 | CASP8 | Intersected target | -1903.8 | -5.8 |
| ZH07 | P37231 | PPARG | Intersected target | -1907.6 | -5.82 |
| ZH08 | Q04206 | RELA | Intersected target | -1752 | -5.34 |
| ZH09 | P10145 | CXCL8 | Intersected target | -1634.7 | -4.98 |
| ZH10 | P01375 | TNF | Intersected target | -1709.5 | -5.21 |
| ZH11 | P40763 | STAT3 | Intersected target | -1832.7 | -5.59 |
| ZH12 | P35354 | PTGS2 | Intersected target | -2061.8 | -6.29 |
| ZH13 | P00797 | REN | Intersected target | -1679.3 | -5.12 |
| ZH14 | P03372 | ESR1 | Intersected target | -2029 | -6.19 |
| ZH15 | P02768 | ALB | Intersected target | -2119.5 | -6.46 |
| ZH16 | P28223 | HTR2A | Intersected target | -2062.3 | -6.29 |
| ZH17 | P15692 | VEGFA | Intersected target | -1511.4 | -4.61 |
| ZH18 | P05231 | IL6 | Intersected target | -1670.7 | -5.09 |
| ZH19 | P00491 | PNP | Drug target | -1974 | -6.02 |
| ZH20 | Q96S37 | SLC22A12 | Drug target | -2020.5 | -6.16 |
| ZH21 | Q9NSA0 | SLC22A11 | Drug target | -1998.5 | -6.09 |
| ZH22 | Q4U2R8 | SLC22A6 | Drug target | -2064.4 | -6.29 |
| ZH23 | Q8TCC7 | SLC22A8 | Drug target | -2110.8 | -6.44 |
| ZH24 | P33527 | ABCC1 | Drug target | -2140.9 | -6.53 |
| ZH25 | Q92887 | ABCC2 | Drug target | -2031.6 | -6.19 |
ABCC1, ATP-binding cassette sub-family C member 1; ABCC2, ATP-binding cassette sub-family C member 2; ALB, albumin; ALDH2, aldehyde dehydrogenase, mitochondrial; CASP8, caspase-8; CXCL8, chemokine (C-X-C motif) ligand 8; ESR1, estrogen; HTR2A, 5-hydroxytryptamine receptor 2A; IL6, interleukin-6; MAOA, monoamine oxidase type A; MAPK8, mitogen-activated protein kinase 8; MMP3, matrix metalloproteinase-3; PNP, purine nucleoside phosphorylase; PPARG, peroxisome proliferator-activated receptor gamma; PTGS2, prostaglandin G/H synthase 2; RELA, transcription factor p65; REN, renin; SLC22A11, solute carrier family 22 member 11; SLC22A12, solute carrier family 22 member 12; SLC22A6, solute carrier family 22 member 6; SLC22A8, solute carrier family 22 member 8; STAT3, signal transducer and activator of transcription 3; TNF, tumor necrosis factor; VEGFA, vascular endothelial growth factor A; XDH, xanthine dehydrogenase.