Table 1.

Mediation effect of Genus-Peptococcus on NSCLC via CD45 on HLA DR⁺ CD4⁺ in TBNK panel.

Total effect	Direct effect A	Direct effect B	Mediation effect	P	Mediated Proportion (%)
β (95% CI)	β (95% CI)	β (95% CI)	β (95% CI)
-0.236 (-0.330 to -0.142)	0.180 (0.103 to 0.257)	-0.189 (-0.229 to -0.149)	-0.034 (-0.070 to -0.005)	0.037	14.44

Total effect: The causal role of GM on NSCLC.

Direct effect A: The causal role of GM on immune cell traits.

Direct effect B: The causal role of immune cell traits on NSCLC.

β(indirect effect) = β(Direct effect A) * β(Direct effect B).

The mediated proportion = β(indirect effect) / β(total effect).