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. Author manuscript; available in PMC: 2024 Nov 21.
Published in final edited form as: Circulation. 2023 Sep 29;148(21):1705–1722. doi: 10.1161/CIRCULATIONAHA.123.065700

Figure 8. Working model of the Gata6-dependent Nkx2–5 A-SHF enhancer gene regulatory network of the outflow tract (OFT).

Figure 8.

GATA6 regulates OFT septation and rotation programs via direct regulation of the Nkx2–5 A-SHF enhancer. A-SHF, anterior second heart field; NCC, neural crest cell.