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. 2005 May 6;33(8):2595–2602. doi: 10.1093/nar/gki546

Figure 1.

Figure 1

(A) Secondary structure model of B.subtilis tyrS leader region and the interaction with tRNA. A Tyr (UAC) specifier sequence in a side bulge of stem–loop I (shown in shadow) base pairs with the anticodon of the cognate tRNA (2,4). Also of importance is the base pairing of the uncharged acceptor end of tRNA with the first four bases (shown in outline) of the antiterminator bulge. This latter interaction also involves covariation of the variable base of the antiterminator (position 222) with the discriminator base of the tRNA (7). (B) Secondary structure of antiterminator model RNA AM1A. The variant model, AM1A(C11U), contains a U at position 11 (corresponding to position 224 in the full leader). These antiterminator model RNAs bind B.subtilis tRNATyr(A73U) in vitro (8) and are functionally relevant in vivo (4). (C) Structure model of B.subtilis tRNATyr(A73U) randomized in D, T and variable loop regions.