Table 3.

Comparison of the "average weighted residual" percent error for the PBPK model (this paper) and the 6 parameter NONMEM model of Schnider et. al. [20]. The PBPK model fits were for both the bolus and the constant infusion input phases, while the NONMEM model fit was for just the constant infusion phase. The PBPK model results are subdivided into the different age groups. The column labeled "Individual Fits" is the error when the model parameters were adjusted for each subject (see figs. 4–6). The column labeled "Average Fits" is the error when one parameter set with a linear age dependence for the fraction of pulmonary sequestration (eq. (13)) was used for all subjects (see figs. 9–11). The "Average Fit" error for the NONMEM model is listed for the case where the same set of 6 parameters were used for all subjects ("No Covariates") or an additional 5 covariate parameters (e.g. weight, height, age, etc) were used ("Covariates").

PBPK Model Bolus + Infusion	Age Group	Individual Fits	Average Fits
	18–34 years	13.5%	18.5%
	35–65 years	16.1%	23.8%
	>65	15.4%	17.6%
	Average	15.0%	20.0%
NONMEM Model Infusion Only [20]		14.18%	23% No Covariates 17.39% 5 Covariates